Mouse Births Pups after Space Mission, Assisting New Research | China Space Station
Of the four mice involved in a recent mission aboard the Tiangong Space Station in orbit, one female has now successfully given birth to healthy offspring on the Earth, the Technology and Engineering Center for Space Utilization (CSU) of the Chinese Academy of Sciences (CAS) has announced.
The four mice were sent into space aboard China's Shenzhou-21 crewed spaceship on Oct. 31, 2025, and were housed in a specialized habitat on the space station before returning to the Earth on Nov. 14.
After their return, one female mated with a male and conceived, and later delivered nine pups on Dec. 10. Six of the newborns have survived—a rate considered normal. Researchers have noted that the mother mouse is nursing normally and the pups appear active and healthy.
"Their offspring all appear normal, so preliminary evidence suggests the space environment may have a very limited impact on the fertility of mice. This lays an important foundation for enabling mice to mate in space in the future, as well as to become pregnant, give birth, and produce offspring there," said Wang Hongmei, deputy director of the Institute of Zoology of the CAS.
According to the CSU, throughout the space mission, an AI-powered monitoring system tracked the behavior of the mice, including movement, feeding and sleep patterns, providing critical data to support real-time decision-making.
The CSU stated that this achievement signifies China's first full-cycle realization of a mammalian space experiment, covering pre-launch preparations, in-orbit operations aboard the Chinese space station, and sample recovery.
This milestone lays a solid foundation for larger-scale mammalian space science experiments in the future, the CSU added.
The monitoring by researchers also revealed that the mother mouse that had been to space showed a parenting style drastically different from that of the ground group. She would seek out a special, hidden and secure corner within her "home" to give birth and would deliberately block the entrance with cotton, appearing exceptionally cautious.
In contrast, the mother mouse from the ground group seemed much more "carefree" with most of her offspring born in cotton nests in open areas.
Scientists will continue to study the postnatal development of the mouse pups, monitoring their growth and physiological changes. Further research may also examine whether these offspring can reproduce normally, helping reveal potential multigenerational effects of space exposure on mammals.
Shenzhou-21 Crew
Zhang Lu (张陆) - Commander & Pilot - 2nd spaceflight
Wu Fei (武飞) Flight Engineer - 1st spaceflight
Zhang Hong Zhang (张洪章) - Payload Specialist - 1st spaceflight
Video Credit: CCTV
Duration: 1 minute, 41 seconds
Release Date: Dec. 28, 2025
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